alpha calcium-calmodulin kinase II (alpha-CaMKII)
No apparent neuroanatomical defects
Intact postsynaptic mechanisms
Intact NMDA receptor function Intact post-tetanic potentiation (a brief form of synaptic modification) Absence or markedly attenuated short-term potentiation, long-term potentiation, and long-term depression Impaired spatial learning Behavioral abnormalities in heterozygous mice Decreased fear response Increase in defensive aggression No measurable cognitive deficits Behavioral abnormalities in homozygous mice
Silva, Paylor, et al., 1992
Silva, Stevens, et al., 1992
Chen et al., 1994
Stevens et al., 1994
| Line Name | DNA Construct | |
|---|---|---|
| 1. | alpha-CaMKII (+/-) | In order to produce mice with a mutation in the alpha-CaMKII locus, plasmid p23 was constucted; p23 contains a 6.1 kb mouse genomic alpha-CaMKII (alpha-calcium-calmodulin.... |
| 2. | alpha-CaMKII (-/-) | In order to produce mice with a mutation in the alpha-CaMKII locus, plasmid p23 was constucted; p23 contains a 6.1 kb mouse genomic alpha-CaMKII (alpha-calcium-calmodulin.... |
