Homozygous mice
Fertile females
Reduced fertility in males
Heterozygous mice
Subnormal blood pressure (15-20 mm Hg) in males
Reduction in serum ACE activity

Krege, 1995

Male-female differences in fertility and blood pressure in ACE-deficient mice.
Nature 375, 146-148 (1995) [95272677]

Kidney obstruction, dilatatin and atrophy
Hydronephrosis
Distortion of arterial vascular tree
Widening and thickening of infrarenal arterial vessels
Accumulation of small renin mRNA
Increased renin mRNA in kidney (32 fold)

Database link:

	Line Name	DNA Construct
1.	ACE (+/-)	A detailed description of the targeting vector is not available.
2.	ACE (-/-)	A detailed description of the targeting vector is not available.
3.	ACE (+/-)	Angiotensin-converting enzyme (Ace) DNA was cloned from strain-129 genomic DNA using a probe made by PCR with primers designed from the mouse genomic sequence. Gene tar....
4.	ACE (-/-)	Angiotensin-converting enzyme (Ace) DNA was cloned from strain-129 genomic DNA using a probe made by PCR with primers designed from the mouse genomic sequence. Gene tar....
5.	RAS (-/-)	The genomic DNAs containing the angiotensinogen locus were isolated from a phage library of C57BL/6 DNA. 418 bp of the 2nd exon and a portion of the preceding intron of....