GENE KNOCKOUT DATABASE
Hepatocellular impairment
Absence of widespread effect in lympoid tissue
Accumulation of ADA substrates in ADA-deficient conceptuses, as early as days 12.5 postcoitum
Accumulation of ADA substrates during late in utero development
Liver damage
Perinatal death
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Wakamiya, 1995
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Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice.
Proc Natl Acad Sci U S A 92, 3673-3677 (1995) [95249535]
| Line Name | DNA Construct | |
|---|---|---|
| 1. | ADA (+/-) | A phage lambda clone carrying a 16.3-kb ADA (adenosine deaminase) DNA fragment was isolated from a genomic library derived from mouse strain 129/Ola. This fragment, str.... |
| 2. | ADA (+/-) | |
| 3. | ADA (-/-) | |
| 4. | ADA (-/-) | A phage lambda clone carrying a 16.3-kb ADA (adenosine deaminase) DNA fragment was isolated from a genomic library derived from mouse strain 129/Ola. This fragment, str.... |
