beta 2-microglobulin
Apparently normal
Fertile
Normal distribution of gamma delta, CD4+8+ and CD4+8- T cells
Normal development of functional TCR(+)-alpha beta CD8+ CTLs in response to tumor cell injection<
Little if any functional MHC I
No detectable class I antigens
Gross deficiency in CD4-CD8+ T cells
Defective CD4-8+ T cell-mediated cytotoxicity
Massive intraperitoneal accumulation of highly lytic CD8+ CTLs after intraperitoneal injection of tumor cells
Delayed tumor cell rejection
Ability to resolve low dose of Listeria monocytogenes
Exacerbated clinical course of L. monocytogenes infection Delayed clearance Impaired vaccine-induced immunity Impaired antigen-induced IFN-gamma secretion Rejection of MCH I-deficient hemopoeitic transplants by normal mice
Koller et al., 1990
Zijlstra et al., 1990
Bix et al., 1991
Apasov and Sitkovsky et al., 1994
Ladel et al., 1994
| Line Name | DNA Construct | |
|---|---|---|
| 1. | Beta[2]-m (+/-) | |
| 2. | Beta[2]-m (-/-) | |
| 3. | beta 2-microglobuli | PMC1polA |
| 4. | beta2-m (+/-) and N | Plasmid pKCbeta2B contains the entire beta2m (beta2-microglobulin) gene within an 8.4-kbp |
