Bax

Viable
Lineage-specific aberrations in cell death
Thymocyte and B-cell hyperplasia
Unusual atretic follicles and excess granulosa cells in ovaries
Infertility in males as a result of disordered seminiferous tubules with an accumulation of atypical premeiotic germ cells
Male germ cell death

Knudson, 1995

Bax-deficient mice with lymphoid hyperplasia and male germ cell death.
Science 270, 96-99 (1995) [96008582]
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( (bax))

	Line Name	DNA Construct
1.	Bax (+/-)	PGK-Neo replaced a 3.7-kb BamHI fragment containing all of exons 2 through 4 and part of exon 5 deleting BH1 and BH2 and the capacity for a functional protein....
2.	Bax (-/-)	PGK-Neo replaced a 3.7-kb BamHI fragment containing all of exons 2 through 4 and part of exon 5 deleting BH1 and BH2 and the capacity for a functional protein....
3.	AATbcl2#32	A 2.9-kb DNA fragment containing an internal poliovirus sequence (ribosome landing pad) followed by a CAT gene and a SV40 poly(A) sequence was purified after PstI