Brain-derived neurotrophic factor (BDNF)
No reduction in motor neurons of facial nucleus or lumbar spinal cord
No reduction in size of cochlear ganglia
Impaired righting ability
Lack of proper coordination of movement and balance
Alternation between periods of hyperactivity and immobility
Reduction in volume of vestibular and trigeminal ganglia
Reduction in volume of nodose-petrosal complex
Failure to thrive beyond postnatal day 8
Death by 3 weeks of age
Conover et al., 1995
Liu et al., 1995
| Line Name | DNA Construct | |
|---|---|---|
| 1. | BDNF (+/-) | The 9.5 kb targeting replacement vector was generated as follows: A neo expression cassette, including the phosphoglycerate kinase promoter and polyadenylation signals,.... |
| 2. | BDNF (-/-) | The 9.5 kb targeting replacement vector was generated as follows: A neo expression cassette, including the phosphoglycerate kinase promoter and polyadenylation signals,.... |
