Calcineurin A alpha

Accumulation of hyperphosphorylated tau primarily in the mossy fibers of hippocampus
Reduced neurofilament protein in the mossy fibers of hippocampus
Unchanged overall level of phosphorylation of neurofilament protein in the mossy fivers of hippocampus
Abnormal cytoskeleton of mossy fivers with a lower neurofilament/microtubule ratio

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