CD3 zeta/eta

 Normal expression of TCR complexes on thymus-independent gut intraepithelial lymphocytes
 Almost total absence of mature single positive thymocytes
 Reduction of surface levels of TCR complexes
 Unusual CD3- T cells in lymph nodes

Malissen et al., 1993


METHODOLOGY ( FROM T-BASE)

Search Results: ( (cd3 zeta/eta))

Line Name DNA Construct
1. TCR CD3-eta (+/-) The targeting vector was made up of a long arm (a 6-kb genomic fragment containing exons 7 and 8 of the zeta/eta gene), a neo gene expression cassette from pMC1neo, a sh....
2. TCR CD3-eta (-/-) The targeting vector was made up of a long arm (a 6-kb genomic fragment containing exons 7 and 8 of the zeta/eta gene), a neo gene expression cassette from pMC1neo, a sh....
3. TCR CD3-eta (+/-) a To generate the eta-T mutation, the targeting vector consisted of a long arm (a 6-kb genomic fragment containing exons 7 and 8 of the zeta/eta gene), a neo gene express....
4. TCR CD3-eta (-/-) a To generate the eta-T mutation, the targeting vector consisted of a long arm (a 6-kb genomic fragment containing exons 7 and 8 of the zeta/eta gene), a neo gene express....
5. CD3 Nef1 #1 The CD3 Nef1 expression vector contains the HIV-1 NL43 nef cloned at XbaI site downstream of the CD3 enhancer/promoter elements in the pNEZ vector and followe....
6. CD3 Nef1 #3.1 The CD3 Nef1 expression vector contains the HIV-1 NL43 nef cloned at XbaI site downstream of the CD3 enhancer/promoter elements in the pNEZ vector and followe....
7. CD3 Nef1 #4 The CD3 Nef1 expression vector contains the HIV-1 NL43 nef cloned at XbaI site downstream of the CD3 enhancer/promoter elements in the pNEZ vector and followe....
8. CD3 Nef1 #5.2 The CD3 Nef1 expression vector contains the HIV-1 NL43 nef cloned at XbaI site downstream of the CD3 enhancer/promoter elements in the pNEZ vector and followe....
9. CD3 Nef1 #2.2 The CD3 Nef1 expression vector contains the HIV-1 NL43 nef cloned at XbaI site downstream of the CD3 enhancer/promoter elements in the pNEZ vector and followe....
10. CD3 Nef1 #3.2 The CD3 Nef1 expression vector contains the HIV-1 NL43 nef cloned at XbaI site downstream of the CD3 enhancer/promoter elements in the pNEZ vector and followe....


Database links: CD3Z

OMIM MEDLINE Citations Protein Links Nucleotide Links Gene Map GDB MEDLINE Neighbors

Database links: CD3H

OMIM MEDLINE Citations MEDLINE Neighbors