CD4


	CD4 Normal fertility Normal T cell proliferative responses Normal IFN-gamma production Enhanced resistance to Trypanosoma brucei brucei Decreased helper cell activity Increased parasite growth and mortality in mice infected with Trypanosoma cruzi Lack of T-cell-dependent immunoglobulin-G-specific responses Rahemtulla et al., 1991 Locksley et al., 1993 Killeen et al., 1993 Rottenberg et al., 1993 Reduced levels of memory cytotoxic T lymphocytes Diminished resistance to subsequent viral challenge von Herrath, 1996 CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge. J Virol 70, 1072-1079 (1996) [96135220] (View Citation format,Abstract format,MEDLARS format,ASN.1 format,Save As..., or 30 Related MEDLINE citations) METHODOLOGY ( FROM T-BASE) Currently, there are no entries for CD4 knockout methodologies in mouse. Database links

CD4

Normal fertility
Normal T cell proliferative responses
Normal IFN-gamma production
Enhanced resistance to Trypanosoma brucei brucei
Decreased helper cell activity
Increased parasite growth and mortality in mice infected with Trypanosoma cruzi
Lack of T-cell-dependent immunoglobulin-G-specific responses

Rahemtulla et al., 1991
Locksley et al., 1993
Killeen et al., 1993
Rottenberg et al., 1993

Reduced levels of memory cytotoxic T lymphocytes

Diminished resistance to subsequent viral challenge

von Herrath, 1996: CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge.
J Virol 70, 1072-1079 (1996) [96135220]
(View Citation format,Abstract format,MEDLARS format,ASN.1 format,Save As..., or 30 Related MEDLINE citations)

METHODOLOGY ( FROM T-BASE)

Currently, there are no entries for CD4 knockout methodologies in mouse.

Database links