CD8


	CD8 Normal fertility of homozygous and heterozygous mice Normal helper cell activity in homozygous mutant mice Normal T cell proliferative responses Normal IFN-gamma production Normal T-cell-dependent immunoglobulin G-specific responses Enhanced IL-4 production after Con-A or anti-CD3 monoclonal antibody stimulation Enhanced resistance to Trypanosoma brucei Lack of CD8+ positive cells in homozygous mutant mice Increased parasite growth and mortality in mice infected with Trypanosoma cruzi Fung-Leung et al., 1991 Rottenberg et al., 1993 METHODOLOGY ( FROM T-BASE) Currently, there are no entries for CD8 knockout methodologies in mouse. Database links

CD8

Normal fertility of homozygous and heterozygous mice
Normal helper cell activity in homozygous mutant mice
Normal T cell proliferative responses
Normal IFN-gamma production
Normal T-cell-dependent immunoglobulin G-specific responses
Enhanced IL-4 production after Con-A or anti-CD3 monoclonal antibody stimulation
Enhanced resistance to Trypanosoma brucei
Lack of CD8+ positive cells in homozygous mutant mice
Increased parasite growth and mortality in mice infected with Trypanosoma cruzi

Fung-Leung et al., 1991
Rottenberg et al., 1993

METHODOLOGY ( FROM T-BASE)

Currently, there are no entries for CD8 knockout methodologies in mouse.

Database links