C/EBP beta (CCAAT/enhancer-binding protein beta)

Normal devlopment
Normal fertility in males
Infertility in females
Lack of corpora luteu
Failure to dow-regulate prostaglandin endoperoxidase synthase 2 and P450 aromatase in response to gonadotropins

Reference:

Sterneck E., Tessarollo L., Johnson PF.: An essential role for C/EBPbeta in female reproduction. Genes Dev 1997 Sep 1;11 (17)2153-2162.

METHODOLOGY ( FROM T-BASE)

Cebpb (+/-) The replacement-type targeting vector consisted of 129/Sv (Stratagene) mouse genomic DNA comprising a 2.0-kb XbaI-NotI fragment of 5' homology and a 5.5-kb NheI-BamHI....

Database Links

OMIM MEDLINE Citations Protein Links Gene Map GDB