c-Fos

c-Fos

Normal function in peripheral T cells

Normal proliferation

Normal cytokine production in response to T cell receptor stimulation

Normal thymocyte development

Normal growth of cells deficient in c-fos protein

Normal levels of expression of mRNA for most Fos and Jun family

Normal overall levels of AP-1 DNA binding activity

Normal expression of genes with functional AP-1 binding site (c-jun, MCP1, metallothionein)

Inability to induce expression of mRNA for metalloproteases (MMP-1, MMP-3) by EGF or PDGF

Jain et al., 1994
Hu et al., 1994

METHODOLOGY ( FROM T-BASE)

((c-fos))

Line Name DNA Construct

1. c-fos (+/-)
2. c-fos (-/-)
3. c-fos (+/-)
4. c-fos (-/-)
5. c-fos The parent plasmid vector used to construct the gene-replacement vector contained the BamHI 3.4-kb fragment of HSV-1 and its TK gene cloned into the NaeI....
6. c-fos (+/-) The parent plasmid vector used to construct the gene-replacement vector contained the BamHI 3.4-kb fragment of HSV-1 and its TK gene cloned into the NaeI....
7. c-fos (-/-) The parent plasmid vector used to construct the gene-replacement vector contained the BamHI 3.4-kb fragment of HSV-1 and its TK gene cloned into the NaeI....

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