CREM

Deficiency in spermiogenesis
Postmeiotic arrest at first step of spermiogenesis
Absence of late spermatids
Significant increase in apoptotic germ cells

Nantel, 1996

Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice.
Nature 380, 159-162 (1996) [96176479]
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( (crem))

	Line Name	DNA Construct
1.	CREM (+/-)	CREM (cyclic AMP-responsive element modulator) genomic clones were isolated from a C57BL/6, lamda-EMBL3 partial Sau3AI library. A 12-kb BamHI frag....
2.	CREM (+/-)	DNA was cloned from a strain 129 genomic library. The targeting construct contains 5.5- and 2.2-kb homology fragments inserted into the pHM3 vector. The deletion disrup....
3.	CREM (-/-)	CREM (cyclic AMP-responsive element modulator) genomic clones were isolated from a C57BL/6, lamda-EMBL3 partial Sau3AI library. A 12-kb BamHI frag....
4.	CREM (-/-)	DNA was cloned from a strain 129 genomic library. The targeting construct contains 5.5- and 2.2-kb homology fragments inserted into the pHM3 vector. The deletion disrup....
5.	CREB (-/-)	The targeting vector consisted of 7.1 kb of mouse CREB (cAMP response element binding protein) genomic DNA and a promoterless neomycin-resistance (Neo) gene inserted in-....
6.	CREB (-/-) hypomorp	The targeting vector consisted of 7.1 kb of mouse CREB (cAMP response element binding protein) genomic DNA and a promoterless neomycin-resistance (Neo) gene inserted in-....