DA (Dopamine)
Viable
Created by inactivation of tyrosine hydroxylase followed by restoration of TH in noradrenergic cells
Apparently normal midbrain dopaminergic neurons
Become hypoactive, adipsic and aphagic after a few weeks
Administration of L-DOPA restores behavior
| Line Name | DNA Construct | |
|---|---|---|
| 1. | TH (+/-) | The mouse tyrosine hydroxylase Th (TH) gene was cloned from a 129Sv/CPJ genomic library by standard colony hybridization procedure using a rat Th cDNA as a probe. An 11.... |
| 2. | TH (-/-) | The mouse tyrosine hydroxylase Th (TH) gene was cloned from a 129Sv/CPJ genomic library by standard colony hybridization procedure using a rat Th cDNA as a probe. An 11.... |
| 3. | MT/RET-304 | The construct consisted of the ret oncogene under the control of the mouse metallothionein (MT)-I promoter. |
| 4. | TH (+/-) | Phage clones containing the mouse TH (tyrosine 3-hydroxylase is a monoxygenase that catalyzes the conversion of tyrosine to 3.4-dihydroxyphenylalanine (DOPA) and require.... |
| 5. | TH (-/-) | Phage clones containing the mouse TH (tyrosine 3-hydroxylase is a monoxygenase that catalyzes the conversion of tyrosine to 3.4-dihydroxyphenylalanine (DOPA) and require.... |
