En-2
Viable
No obvious defects in embryonic development
Abnormal foliation in adult cerebellum
Joyner et al., 1991
| Line Name | DNA Construct | |
|---|---|---|
| 1. | En-2 (hd) (+/-) | The En-2 mutation created by homologous recombination resulted in the replacement of approximately 1-kb of the engrailed-2 En-2 gene, consisting of 300-bp of intron and.... |
| 2. | En-2 (ntd) (-/-) | An exon 1 En-2 (engrailed-2) targeting vector of the positive/negative type (G00-372-934) was made from genomic DNA from C3H strain mice. The vector contained a neo cas.... |
| 3. | En-2 (hd) (-/-) | The En-2 mutation created by homologous recombination resulted in the replacement of approximately 1-kb of the engrailed-2 En-2 gene, consisting of 300-bp of intron and.... |
| 4. | En-2 (ntd) (+/-) | An exon 1 En-2 (engrailed-2) targeting vector of the positive/negative type (G00-372-934) was made from genomic DNA from C3H strain mice. The vector contained a neo cas.... |
| 5. | En-2 (hd) (-/-) | The En-2 mutation created by homologous recombination resulted in the replacement of approximately 1-kb of the engrailed-2 En-2 gene, consisting of 300-bp of intron and.... |
| 6. | En-2 (+/-) | The vector contains the bacterial neomycin-resistance gene (neo) driven by a 500-bp fragment of the human beta-actin promoter (beta-neo) flanked on one side by a 3-kb En.... |
