Estrogen receptor

Survival to adulthood

Normal gross external phenotypes

Infertility in males

Infertility in females

Hypoplastic uteri

Hyperemic ovaries

No detectable corpora lutea

Lack of response of uterus and vagina to estradiol treatment

Lubahn et al., 1993
Korach, 1994
Eddy, T. F. Washburn, D. O. Bunch, E. H. Goulding, B. C. Glanden, D. B. Lubahn & K.S. Korach: Targeted Disruption of the Estrogen Receptor Gene in Male Mice Causes Alteration of Spermatogenesis and Infertility. Endocrinology 137, 4796-4805 (1996)

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METHODOLOGY ( FROM T-BASE)

((estrogen receptor))

	Line Name	DNA Construct
1.	ER (+/-)	The mouse estrogen receptor (ER) has been cloned and found to have nine exons. Utilizing the published sequence and PCR with oligonucleotide primer pairs 1-2 and 3-4 (wh....
2.	ER (-/-)	The mouse estrogen receptor (ER) has been cloned and found to have nine exons. Utilizing the published sequence and PCR with oligonucleotide primer pairs 1-2 and 3-4 (wh....

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Database links