FRONTIERS IN BIOSCIENCE;
GENE KNOCKOUT DATABASE





Glial fibrillary acidic protein (GFAP)

Normal development
Normal fertility
Absence of gross alteration in behavior or CNS morphology
Severly reduced number of intermediate filaments in astrocytes of CNS
Enhancement of long-term potentiation of both population spike amplitude and excitatory post-synaptic potential slope compared to control

McCall, 1996
Targeted deletion in astrocyte intermediate filament (Gfap) alters neuronal physiology.
Proc. Natl. Acad. Sci. U.S.A. 93, 6361-6366 (1996) [96270543]

METHODOLOGY ( FROM T-BASE)

Search Results: ( (gfap))

Line Name DNA Construct
1. Gfap(tm1Mes) (+/-) The GFAP targeting vector was constructed from a genomic clone isolated from a 129/SvEv genomic library. The targeting vector contains PGKneobpA (Soriano et al., 1991;....
2. Gfap (tm1Mes) (-/-) The GFAP targeting vector was constructed from a genomic clone isolated from a 129/SvEv genomic library. The targeting vector contains PGKneobpA (Soriano et al., 1991;....


Database Links

OMIM MEDLINE Citations Protein Links Nucleotide Links Gene Map GDB 30 MEDLINE Neighbors