GLUT4

Retardation of growth in mice
Decreased longevity, cardiac hypertrophy, and severely reduced adipose tissue deposits
Absence of significant elevation of blood glucose levels in female mice in the fed and fasting states
Moderately reduced glycemias in the fasted state and increased glycemias in the fed state of male mice
Postprandial hyperinsulinemia in male and female mice

Katz, 1995

Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4
Nature 377, 151-155 (1995) [95405466]
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( (glut4))

	Line Name	DNA Construct
1.	GLUT4 (+/-)	The murine GLUT4 (glucose transporter-4) gene and promoter were cloned by plaque hybridization to the rat GLUT4 complementary DNA from a genomic 129/Sv lambda library.
2.	aP2/Ha-ras (mod)	The adipose-specific Ha-ras transgene was constructed using the fat-specific promoter/enhancer from the fatty acid-binding protein gene, alpha-P2 (gift of Dr. B.M. Spieg....
3.	GLUT4 (-/-)	The murine GLUT4 (glucose transporter-4) gene and promoter were cloned by plaque hybridization to the rat GLUT4 complementary DNA from a genomic 129/Sv lambda library.
4.	aP2/Ha-ras (high)	The adipose-specific Ha-ras transgene was constructed using the fat-specific promoter/enhancer from the fatty acid-binding protein gene, alpha-P2 (gift of Dr. B.M. Spieg....