HOXA9

Heterozygous

Lack of hematopoietic defects

Homozygous

30%-40% reduction in total leukocytes and lymphocytes
Blunted granulocytic response to granulocyte colony-stimulating factor (G-CSF)
Reduced size of spleen
Reduced size of thymus
Significantly reduced myeloid erythroid and pre-B progenitors in marrow

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