Hsp 70-2

Hsp 70-2

Homozygous male mice

Absence of postmeiotic spermatids and mature sperm

Infertile

Structural abnormalities visible by late prophase

Failed meiosis

Increased spermatocyte apoptosis

Homozygous female mice

Unaffected meiosis and fertility

Dix, 1996: Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility.
Proc. Natl. Acad. Sci. U.S.A. 93, 3264-3268 (1996) [96194955]
(View Citation format,Abstract format,MEDLARS format,ASN.1 format,Save As..., or 30 Related MEDLINE citations)

Infertile males

Lack of spermatids and spermatozoa

Increased apoptosis in the spermatogonia

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METHODOLOGY ( FROM T-BASE)

( (hsp70-2))

( (hsp70-2))

Line Name DNA Construct

1. Hsp70-2/lacZ ( Genomic clones of Hsp70-2 were isolated from a B6/CBA mouse genomic library (Stratagene). Digestion of a subclone with BamHI and DrdI yielded a 2.....
2. Hsp70-2/Lac Z ( Genomic clones of Hsp70-2 were isolated from a B6/CBA mouse genomic library (Stratagene). Digestion of a subclone with BamHI and DrdI yielded a 2.....
3. Hsp70-2/lacZ ( Genomic clones of Hsp70-2 were isolated from a B6/CBA mouse genomic library (Stratagene). Digestion of a subclone with BamHI and DrdI yielded a 2.....

Database links