ICAM-1

Normal growth and fertility
Moderate granulocytosis
Prominent abnormalities in inflammatory responses

Sligh et al., 1993

Protection from acute renal ischemic injury as judged by serum creatinine, renal histology, and animal survival
Reduction in renal leukocyte infiltration

Kelly, W. W. Williams, Jr., R. B. Colvin, S. M. Meehan, T. A. Springer, J. Gutierrez-Ramos & J. V. Bonventre: Intercellular Adhesion Molecule-1--deficient Mice Are Protected against Ischemic Renal Injury. J. Clin. Invest. 97, 1056-63 (1996)

((icam-1))

	Line Name	DNA Construct
1.	K14/ICAM-1 I13	A 1.9-kb cDNA for mouse ICAM-1 containing all coding sequences and a stop codon, was converted into a BamHI fragment with linkers and cloned into a single
2.	K14/ICAM-1 I31	A 1.9-kb cDNA for mouse ICAM-1 containing all coding sequences and a stop codon, was converted into a BamHI fragment with linkers and cloned into a single
3.	K14/ICAM-1 I12	A 1.9-kb cDNA for mouse ICAM-1 containing all coding sequences and a stop codon, was converted into a BamHI fragment with linkers and cloned into a single
4.	K14/ICAM-1 I21	A 1.9-kb cDNA for mouse ICAM-1 containing all coding sequences and a stop codon, was converted into a BamHI fragment with linkers and cloned into a single
5.	ICAM-1 (+/-)	To prepare the targeting construct, a 5.5-kb segment of the ICAM-1 gene containing exons 4-7 was cloned into pBluescript ll KS(--) (Stratagene). A neomycin-resistance....
6.	ICAM-1 (-/-)	To prepare the targeting construct, a 5.5-kb segment of the ICAM-1 gene containing exons 4-7 was cloned into pBluescript ll KS(--) (Stratagene). A neomycin-resistance....