IL-6

Normal fertility
No apparent change in TNF-alpha induced metabolic change or lethality
Protection from bone loss after estrogen depletion
Reduced TNF-alpha induced corticosterone production

Impairment of immune and acute phase responses

Significant reduction of acute phase protein in response to turpentine, TNF, or IL-1

((il-6))

	Line Name	DNA Construct
1.	IL-6 (+/-)	The IL-6 (interleukin-6) target vector with a short arm and long arm homology of 1.4 kb and 8.5 kb, respectively, contains the neo cassette cloned in exon 2 (first codin....
2.	IL-6 (-/-)	An IL-6 genomic clone derived from a Balb/c genomic library was used a source of IL-6 genomic sequences. The 5' homology, a 1-kb SpeI-AatII fragme....
3.	IL-6 (+/-)	An IL-6 genomic clone derived from a Balb/c genomic library (G00-097-505) was used as a source of IL-6 genomic sequences. The 5' homology, a 1 kb SpeI-A....
4.	IL-6 (-/-)	The IL-6 (interleukin-6) target vector with a short arm and long arm homology of 1.4 kb and 8.5 kb, respectively, contains the neo cassette cloned in exon 2 (first codin....
5.	IL-6 (-/-)	An IL-6 genomic clone derived from a Balb/c genomic library (G00-097-505) was used as a source of IL-6 genomic sequences. The 5' homology, a 1 kb SpeI-A....
9.	NF-IL6 (-/-)	An 11 kb genomic fragment spanning from 8.5 kb 5' of the NF-IL6 transcription initiation site to 2.3 kb 3' of the end of the exon was subcloned into pUC18 plasmid vector....