Beta1 integrin
Heterozygous mice
Indistinguishable from normal mice Homozygous mice
Normal development to blastocyst stage
Normal implantation
Invasion of uterine basement membrane
Death shortly after implantation
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Fassler, 1995
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Consequences of lack of beta 1 integrin gene expression in mice.
Genes Dev 9, 1896-1908 (1995) [95377640]
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Heterozygous mice
Normal Homozygous mice
Formation of normal-looking blastocysts
Initiation of implantation at E4.5
Collapsed blastocoels and defective endoderm morphogenesis and migration in E4.5 beta-1 null embryos
Extensive degeneration in E5.5 beta-1 null embryos
Normal trophoblast function in -null peri-implantation embryos
Retarded growth and defective extraembryonic endoderm morphogenesis in inner cell masses of beta-1-null blastocysts
Lethality during early postimplantation development
- Stephens, 1995
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Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality.
Genes Dev 9, 1883-1895 (1995) [95377639]
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Normal
Homozygous
Normal looking blastocysts
Normal initial implantation (penetration of uterine epithelium)
Lack of extensive decidual invasion
Collapsed blastocoeles at E4.5
Defective endodermal morphogenesis and migration
Normal In vitro trophoblast function
Lethality during early postimplantation
Database link:
| Line Name | DNA Construct | |
|---|---|---|
| 1. | Integrin beta-1 (+ | Two targeting vectors were made for the disruption of the beta-1 integrin locus. The first targeting vector contained a promotorless beta-galactosidase-neomycin fusion.... |
| 2. | Integrin alpha-1 (+ | A 1.8-kb human integrin alpha-1 cDNA (gift of E. Marcantonio, REG:104183) was used to probe a mouse cDNA library. Three overlapping cDNA clones were isolated, sequenced.... |
| 3. | Integrin beta-1 (-/ | Two targeting vectors were made for the disruption of the beta-1 integrin locus. The first targeting vector contained a promotorless beta-galactosidase-neomycin fusion.... |
| 4. | Integrin alpha-1 (- | A 1.8-kb human integrin alpha-1 cDNA (gift of E. Marcantonio, REG:104183) was used to probe a mouse cDNA library. Three overlapping cDNA clones were isolated, sequenced.... |
