Insulin receptor substrate-1 (IRS-1)
Born alive
Reduced intrauterine growth (50%)
Retardation of postnatal growth
Impaired glucose tolerance
Decrease in insulin/IGF-1 stimulated glucose uptake in vivo and in vitro (Araki et al., 1994)
Resistance to glucose-lowering effects of insulin, IGF-1, and IGF-2 (Tamemoto et al, 1994)
Araki et al., 1994
Tamemoto et al., 1994
| Line Name | DNA Construct | |
|---|---|---|
| 1. | IRS-1 (+/-) | The mouse IRS-1 (insulin-receptor substrate-1) gene containing the 5' flanking region, first exon and a part of the first intron was cloned as described by Araki et al (.... |
| 2. | IRS-1 (+/-) | The mouse IRS-1 (insulin receptor substrate-1) gene was cloned from BALB/c mouse genomic library using a 400 bp PCR product flanking the ATG translation initiation codo.... |
| 3. | IRS-1 (-/-) | The mouse IRS-1 (insulin-receptor substrate-1) gene containing the 5' flanking region, first exon and a part of the first intron was cloned as described by Araki et al (.... |
| 4. | IRS-1 (-/-) | The mouse IRS-1 (insulin receptor substrate-1) gene was cloned from BALB/c mouse genomic library using a 400 bp PCR product flanking the ATG translation initiation codo.... |
