Low density lipoprotein receptor

Normal fertility
Normal triglyceride concentrations
Increased susceptibility to gross atheromata in aorta and coronary ostia
Increased susceptibility to thickening of aortic valve leaflets
Increased susceptibility to increased plasma VLDL, IDL, and LDL cholesterol
Increased total plasma cholesterol concentration
Increased susceptibility to develop massive xanthomatous infiltration of skin and subcutaneous tissues

Ishibashi et al., 1993
Ishibashi et al., 1994

((ldlr))

	Line Name	DNA Construct
1.	LDLR (+/-)	Mouse LDL (low density lipoprotein) receptor cDNA was amplified by PCR from mouse liver first strand cDNA using polyA+ RNA and the following primers: Primer A (5'-ATTCT....
2.	LDLR (-/-)	Mouse LDL (low density lipoprotein) receptor cDNA was amplified by PCR from mouse liver first strand cDNA using polyA+ RNA and the following primers: Primer A (5'-ATTCT....