Mannose 6-phosphate receptor
No apparent phenotypic trait
Increased levels of phosphorlyated lysozomal enymes in body fluids
Marked increase in the amount of phophorylated lysozomal enyzmes secreted by thymocytes and fibroblasts
Decreased intracellular levels of multiple lysozomal enzymes in fibroblasts in vitro
Accumulation of macromolecules in fibroblasts in vitro
Ludwig et al., 1993
Koster et al., 1993
| Line Name | DNA Construct | |
|---|---|---|
| 1. | MPR46 (+/-) | A genomic library (lambda G13) containing the MPR46 (mannose 6-phosphate receptors (MPRs)) gene was isolated from a genomic library of mouse PCC4 teratocarcinoma cells d.... |
| 2. | MPR46 (-/-) | A genomic library (lambda G13) containing the MPR46 (mannose 6-phosphate receptors (MPRs)) gene was isolated from a genomic library of mouse PCC4 teratocarcinoma cells d.... |
