mdr1a P-glycoprotein
Viable
Fertile
Phenotypically normal
Increased sensitivity to the centrally neurotoxic pesticide ivermectin (100-fold) and the carcinostatic drug vinblastine (3-fold)
| Line Name | DNA Construct | |
|---|---|---|
| 1. | mdr1a (+/-)/hygro | mdr1a genomic sequences were isolated from an EMBL-3 lambda phage library constructed from DNA from a mouse strain 129-derived CCE ES cell line. mdr1a sequences were id.... |
| 2. | mdr1a (-/-)/hygro | mdr1a genomic sequences were isolated from an EMBL-3 lambda phage library constructed from DNA from a mouse strain 129-derived CCE ES cell line. mdr1a sequences were id.... |
