mGluR1
Mutant mice are viable
Normal voltage-gated Ca2+ channels of Purkinje cells
Normal plasticity to paired stimulation
Normal parallel fiber and climbing fiber synapses
Normal gross anatomy of hippocampus
Normal excitatory synaptic transmission
Normal long term depression
Normal short term potentiation in the hippocampal CA1 region
Cerebellar symptoms (ataxic gait, intention tremor)
Deficient long-term depression
Impaired eyeblink response
Reduced long-term potentiation
Moderate impairment of context-specific associative learning
Aiba , Kano, et al., 1994
Aiba, Chen, et al., 1994
| Line Name | DNA Construct | |
|---|---|---|
| 1. | mGluR1 (+/-) | Mouse mGluR1 genomic fragments were isolated from a 129/Sv DNA library screened with oligonucleotides from the rat cDNA sequence. The targeting vector was constructed b.... |
| 2. | mGluR1 (+/-) | A genomic fragment containing exon 1 of mGluR1 (metabotropic glutamate receptor 1) was isolated from a genomic EMBL3 phage DNA library prepared from D3 ES cells (Silva e.... |
| 3. | mGluR-1 (-/-) | Mouse mGluR1 genomic fragments were isolated from a 129/Sv DNA library screened with oligonucleotides from the rat cDNA sequence. The targeting vector was constructed b.... |
| 4. | mGluR1 (-/-) | A genomic fragment containing exon 1 of mGluR1 (metabotropic glutamate receptor 1) was isolated from a genomic EMBL3 phage DNA library prepared from D3 ES cells (Silva e.... |
| 5. | mGluR1 (-/-) | A genomic fragment containing exon 1 of mGluR1 (metabotropic glutamate receptor 1) was isolated from a genomic EMBL3 phage DNA library prepared from D3 ES cells (Silva e.... |
