FRONTIERS IN BIOSCIENCE;
GENE KNOCKOUT DATABASE





MLH1

Normal mating behavior in males
Absence of mature sperm
Normal estrous cycles in females
Normal reproductive and mating behavior in females
Infertility in females
Cells enter meiotic prophase and arrest at pachytene
Replication error phenotype

Edelmann, 1996
Meiotic pachytene arrest in MLH1-deficient mice.
Cell 85, 1125-1134 (1996) [96270514]

METHODOLOGY ( FROM T-BASE)

Search Results: ( (mlh1))

Line Name DNA Construct
1. Mlh1 (+/-) Using mouse Mlh1 cDNA, a genomic clone was isolated from a 129/Sv strain library (lambda-FIXII, Stratagene) that contained the first five exons of the open reading frame....
2. Mlh1 (-/-) Using mouse Mlh1 cDNA, a genomic clone was isolated from a 129/Sv strain library (lambda-FIXII, Stratagene) that contained the first five exons of the open reading frame....


Database Links

OMIM MEDLINE Citations Protein Links Nucleotide Links HGMD Gene Map GDB 30 MEDLINE Neighbors