Metallothionein I and II (MT I and MT II)
Viable
Phenotypically normal
Fertile
Increased susceptibility to cadmium toxicity
Michalska and Choo, 1993
Masters et al., 1994
| Line Name | DNA Construct | |
|---|---|---|
| 1. | MT-I/MT-II (+/-) | To disrupt the MT-II (metallothionein II) gene, oligonucleotides 52 (5'-GATCCACGGTTGACTAAGCTA-3') and 53 (5'-GATCTAGCTTCGTCAACGTG-3') were annealed and then ligated into.... |
| 2. | MT-I/MT-II (-/-) | To disrupt the MT-II (metallothionein II) gene, oligonucleotides 52 (5'-GATCCACGGTTGACTAAGCTA-3') and 53 (5'-GATCTAGCTTCGTCAACGTG-3') were annealed and then ligated into.... |
| 3. | MT-I & MT-II (+/-) | Starting with the 10-kb pK-H genomic clone containing the mouse metallothioneins (MT-l and MT-ll) genes (G00-098-538), the MT-l gene was disrupted using a pair of 20 bp.... |
| 4. | MT-I & MT-II (-/-) | Starting with the 10-kb pK-H genomic clone containing the mouse metallothioneins (MT-l and MT-ll) genes (G00-098-538), the MT-l gene was disrupted using a pair of 20 bp.... |
| 5. | MT/RET-242 | The construct consisted of the ret oncogene under the control of the mouse metallothionein (MT)-I promoter. |
| 6. | MT/RET-192 | The construct consisted of the ret oncogene under the control of the mouse metallothionein (MT)-I promoter. |
| 7. | MT/RET-319 | The construct consisted of the ret oncogene under the control of the mouse metallothionein (MT)-I promoter. |
| 8. | MT/RET-304 | The construct consisted of the ret oncogene under the control of the mouse metallothionein (MT)-I promoter. |
| 9. | MT-TGF-alpha line M | The 917 bp cDNA encoding unprocessed human TGF-alpha (Transforming Growth Factor-alpha) was removed from the plasmid phTGF1-10-925 (a gift from Dr. Graeme I. Bell, G00-0.... |
| 10. | MT-TGF-alpha line M | The 917 bp cDNA encoding unprocessed human TGF-alpha (Transforming Growth Factor-alpha) was removed from the plasmid phTGF1-10-925 (a gift from Dr. Graeme I. Bell, G00-0.... |
| 11. | MT-TGF-alpha line M | The 917 bp cDNA encoding unprocessed human TGF-alpha (Transforming Growth Factor-alpha) was removed from the plasmid phTGF1-10-925 (a gift from Dr. Graeme I. Bell, G00-0.... |
| 12. | MT-TGF-alpha line M | The 917 bp cDNA encoding unprocessed human TGF-alpha (Transforming Growth Factor-alpha) was removed from the plasmid phTGF1-10-925 (a gift from Dr. Graeme I. Bell, G00-0.... |
