Neurotrophin-4 (NT4)

Normal and long lived
No obvious neurological defects
No effect on motor neurons of the facial nucleus and sympathetic neurons of the superior cervical ganglion
No obvious loss of dopaminergic neurons in the substantia nigra
No reduction in size of vestibular, trigeminal, or cochlear ganglia
No reduction in motor neurons of the facial nucleus or lumbar spinal cord
Loss of sensory neurons in the nodose-petrosal and geniculate ganglia

Conover et al., 1995
Liu et al., 1995

((nt4))

	Line Name	DNA Construct
1.	NT4 (-/-)	The 11-kb replacement type targeting vector carries a neo gene driven by a phosphoglycerate kinase promoter, which replaced the BglII-HindIII DNA f....
2.	NT4 (+/-)	The 11-kb replacement type targeting vector carries a neo gene driven by a phosphoglycerate kinase promoter, which replaced the BglII-HindIII DNA f....