GENE KNOCKOUT DATABASE
Healthy appearance
Normal fertility
Ability to care for offsprings
Normal stress-induced analgesia
Significant behavioral abnormalities
Increased anxiety
Increased offensive aggressiveness in males
Marked differences in supraspinal, but not in spinal, responses to painful stimuli as compared to controls
Konig, A. M. Zimmer, H. Steiner, P. V. Holmes, J. N. Crawley, M. J. Brownstein & A. Zimmer:
Pain responses, anxiety and aggression in mice deficient in pre-proenkephalin.
Nature 383, (1996)
| Line Name | DNA Construct | |
|---|---|---|
| 1. | enk (+/-) | The targeting vector was derived from pPNT (Tybulewicz et al., 1991; CIT:354802) by introducing a 6.2-kb genomic fragment containing exons I and II upstream, and a 1.3-k.... |
| 2. | enk (-/-) | The targeting vector was derived from pPNT (Tybulewicz et al., 1991; CIT:354802) by introducing a 6.2-kb genomic fragment containing exons I and II upstream, and a 1.3-k.... |
