p21CIP1/WAF1
Normal development
Thymocytic apoptosis and mitotic spindle ckeckpoint appear normal
Absence of spontaneous malignancies during seven months of observation
Embryonic fibroblasts deficient in ability to arrest in G1 in response to DNA damage and nucleotide pool perturbation
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Deng, 1995
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Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control.
Cell 82, 675-684 (1995) [95393479]
(View Citation format,Abstract format,MEDLARS format,ASN.1 format,Save As..., or 30 Related MEDLINE citations )
| Line Name | DNA Construct | |
|---|---|---|
| 1. | p21 (CIP1/WAF1) (+/ | Recombinant phage containing genomic DNA of the p21 locus were isolated from a 129 mouse library (Stratagene) by using a 454 bp fragment containing the second exon of th.... |
| 2. | p21 (CIP1/WAF1) (-/ | Recombinant phage containing genomic DNA of the p21 locus were isolated from a 129 mouse library (Stratagene) by using a 454 bp fragment containing the second exon of th.... |
