Ten-fold elevation of CDK2 activity in thymocytes
Enlargement of thymus, pituitary, adrenal glands, and gonadal organs
Sterility caused by impaired development of ovarian follicles
Spontaneous development of pituitary tumors, similar to mice with Rb mutation
Disturbed organization of the normal cellular layer pattern in retina

Nakayama, 1996

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors.
Cell 85, 707-720 (1996) [96234230]

Search Results: ( (kip1))

	Line Name	DNA Construct
1.	p27 (+/-)	A 129/Sv mouse genomic library (Stratagene) was screened with p27 (kip1) cDNA as a probe. Of 3x10(6) phages screened, a recombinant phage containing genomic DNA of the....
2.	p27 (+/-)	A 17 kb NotI fragment containing the entire coding region of the p27 gene was obtained from a mouse 129/Sv lambda genomic library (obtained from Paul Stein) u....
3.	p27(Kip1) (+/-)	Kiyokawa et al (1996) isolated the mouse p27 gene by screening a 129 mouse genomic library (Stratagene) using the total coding region of mouse p27 cDNA as a probe. A 6.....
4.	p27 (-/-)	A 129/Sv mouse genomic library (Stratagene) was screened with p27 (kip1) cDNA as a probe. Of 3x10(6) phages screened, a recombinant phage containing genomic DNA of the....
5.	p27 (-/-)	A 17 kb NotI fragment containing the entire coding region of the p27 gene was obtained from a mouse 129/Sv lambda genomic library (obtained from Paul Stein) u....
6.	p27(Kip1)	Kiyokawa et al (1996) isolated the mouse p27 gene by screening a 129 mouse genomic library (Stratagene) using the total coding region of mouse p27 cDNA as a probe. A 6.....