p53

No change in susceptibility to induction of mammary tumors by DMBA in hemizygous mice

Rapid development of spontaneous tumors

Delay in tumor onset and subsequent mortality in response to caloric restriction

Increase in the number of splenocytes in S-phase
Reduction in the number of splenocytes in S-phase in response to caloric intake

Defects in neural tube closure in some embryos

Excencephaly

Attenuation of methamphetamine-induced serotonin neurotoxicity

Reference:

Hirata H, Cadet JL.: Methamphetamine-induced serotonin neurotoxicity is attenuated in p53 knockout mice. Brain Res 1997 Sep 12;768 (1-2):345-348.

((p53))

	Line Name	DNA Construct
1.	p53 (-/-)	The p53 targeting vector was constructed by insertion of the 3.7-kb XhoI (exon 2)-SacII (exon 10) murine genomic p53 DNA fragment into pBluescript....
2.	p53 (+/-) (skin tum	The p53 targeting vector was constructed by insertion of the 3.7-kb XhoI (exon 2)-SacII (exon 10) murine genomic p53 DNA fragment into pBluescript....
3.	p53 (+/-)	The p53 targeting vector was constructed by insertion of the 3.7-kb XhoI (exon 2)-SacII (exon 10) murine genomic p53 DNA fragment into pBluescript....
4.	p53 (-/-) (skin tu	The p53 targeting vector was constructed by insertion of the 3.7-kb XhoI (exon 2)-SacII (exon 10) murine genomic p53 DNA fragment into pBluescript....
5.	p53 (-/-)	The p53 targeting vector was constructed by insertion of the 3.7-kb XhoI (exon 2)-SacII (exon 10) murine genomic p53 DNA fragment into pBluescript....
6.	p53 (+/-) and radia	The p53 targeting vector was constructed by insertion of the 3.7-kb XhoI (exon 2)-SacII (exon 10) murine genomic p53 DNA fragment into pBluescript....
7.	p53 (+/-)	Two targeting vectors were used in this study, namely pCPR3.1 and pCPR5.1. The first one, vector pCPR3.1 used to generate clone R72 was created by ligation of a Hi....
8.	p53 (-/-) and radia	The p53 targeting vector was constructed by insertion of the 3.7-kb XhoI (exon 2)-SacII (exon 10) murine genomic p53 DNA fragment into pBluescript....
9.	p53 (-/-) (C57BL/6,	p53-deficient mice were generated as described in G00-321-237. Briefly, the targeting vector consists of an insertion of a PolII promoter-driven neo cassette into the m....
10.	p53 (-/-)	Two targeting vectors were used in this study, namely pCPR3.1 and pCPR5.1. The first one, vector pCPR3.1 used to generate clone R72 was created by ligation of a Hi....
11.	p53 (-/-)	The p53 targeting vector was constructed by insertion of the 3.7-kb XhoI (exon 2)-SacII (exon 10) murine genomic p53 DNA fragment into pBluescript....
12.	p53 (-/-) exencepha	The p53 targeting vector was constructed by insertion of the 3.7-kb XhoI (exon 2)-SacII (exon 10) murine genomic p53 DNA fragment into pBluescript....
13.	p53 (-/-) (129/Sv)	p53-deficient mice were generated as described in G00-321-237. Briefly, the targeting vector consists of an insertion of a PolII promoter-driven neo cassette into the m....
14.	p53 (+/-)	The p53 targeting vector was constructed by insertion of the 3.7-kb XhoI (exon 2)-SacII (exon 10) murine genomic p53 DNA fragment into pBluescript....