PDE gamma
Reduced PDE activity in mice
Lack of hydrolytic activity in PDE alpha beta dimer
Rapid retinal degeneration resembling human retinitis pigmentosa
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Tsang, 1996
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Retinal degeneration in mice lacking the gamma subunit of the rod cGMP phosphodiesterase.
Science 272, 1026-1029 (1996) [96208623]
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| Line Name | DNA Construct | |
|---|---|---|
| 1. | Pdeg (tm1)/+ | A 0.48-kb Pdeg (cyclic guanosine 3',5'-monophosphate (cGMP) phosphodiesterase) complementary DNA (cDNA) fragment was used to isolate a 16-kb genomic DNA from a mouse lam.... |
| 2. | Pdeg (tm1)/Pdeg (tm | A 0.48-kb Pdeg (cyclic guanosine 3',5'-monophosphate (cGMP) phosphodiesterase) complementary DNA (cDNA) fragment was used to isolate a 16-kb genomic DNA from a mouse lam.... |
