Normal responses to flunitrazepam or pentobarbital
Reduction of immunoactivity in cerebellum to undetectable levels without alteration to levels of beta1, or beta2 isoforms
Reduction of sensitivity to effects of ethanol

Impaired elimination of multiple climbing fiber innervation of cerebellar

Harris, 1995

Mutant mice lacking the gamma isoform of protein kinase C show decreased behavioral actions of ethanol and altered function of gamma-aminobutyrate type A receptors
Proc Natl Acad Sci U S A 92, 3658-3662 (1995) [95249532]

Annika B, 1997

Preserved acute pain and reduce neuropathic pain in mice lacking PKCg
Science 278, 279-283, 1997

Preserved acute pain
Reduced neuropathic pain

Reference:

Malmberg AB, Chen C, Tonegawa S, Basbaum AI.: Preserved acute pain and reduced neuropathic pain in mice ladking PKCgamma. Science 1997 Oct 10;278 (5336):279-283.

( (pkc-gamma))

	Line Name	DNA Construct
1.	PKC-gamma (+/-)	Calcium-phospholipid-dependent protein kinase subtype gamma was cloned from a 129/Ola mouse genomic cosmid library with a rat PKC-gamma cDNA probe. The exon structure w....
2.	PCK-gamma (+/-) & l	Calcium-phospholipid-dependent protein kinase subtype gamma was cloned from a 129/Ola mouse genomic cosmid library with a rat PKC-gamma cDNA probe. The exon structure w....
3.	PKC-gamma (-/-)	Calcium-phospholipid-dependent protein kinase subtype gamma was cloned from a 129/Ola mouse genomic cosmid library with a rat PKC-gamma cDNA probe. The exon structure w....
4.	PKC-gamma (-/-) (et	Calcium-phospholipid-dependent protein kinase subtype gamma was cloned from a 129/Ola mouse genomic cosmid library with a rat PKC-gamma cDNA probe. The exon structure w....
5.	PCK-gamma (-/-) & l	Calcium-phospholipid-dependent protein kinase subtype gamma was cloned from a 129/Ola mouse genomic cosmid library with a rat PKC-gamma cDNA probe. The exon structure w....