Gorry P, Lufkin T, Dierich A, Rochette-Egly C, Decimo D, Dolle P, Mark M, Durand B, Chambon P:
The cellular retinoic acid binding protein I is dispensable.
Proceedings of the National Academy of Sciences of the United States of
America 1994 Sep 13;91(19):9032-6
ABSTRACT
The cellular retinoic acid binding proteins I and II (CRABPI and
CRABPII) bind retinoic acid with high affinity, exhibit distinct
patterns of expression during embryonic development, and are thought
to play important roles in the RA signaling pathway. We have
generated a targeted mutation of the CRABPI gene using the
"hit-and-run" strategy and shown that it prevents the production of
a functional CRABPI protein. Homozygous mutant mice were normal,
indicating that CRABPI does not play a crucial role in the RA
signaling pathway.
