Stat1
Normal response to other cytokines that activate STAT1 in vitro
Absence of overt developmental abnormalities in mice
Lack of responsiveness to IFN alpha or IFN gamma
High sensitivity to infection by microbial pathogens and viruses
Unexpected physiologic specificity in the JAK-STAT signaling pathway
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Meraz, 1996
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Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway.
Cell 84, 431-442 (1996) [96190810]
(View Citation format,Abstract format,MEDLARS format,ASN.1 format,Save As..., or 30 Related MEDLINE citations )
Homozygotes born at normal frequencies Absence of gross developmental defects Failure to thrive Extreme susceptibility to viral disease Cells and tissues unresponsive to interferon Responsive to all other tested cytokines
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Durbin, 1996
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Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease.
Cell 84, 443-450 (1996) [96190811]
(View Citation format,Abstract format,MEDLARS format,ASN.1 format,Save As..., or 30 Related MEDLINE citations )
| Line Name | DNA Construct | |
|---|---|---|
| 1. | Stat1 (+/-) | Genomic clones containing portions of the murine Stat1 gene were isolated from a lambdaFix II murine 129/Sv genomic library (Stratagene) by screening the library using t.... |
| 2. | Stat1 (+/-) | A genomic library from strain 129 mice (Stratagene) was screened with a partial cDNA clone for mouse Stat1 (provided by C. Schindler). A 16.5 kb genomic clone (412C) en.... |
| 3. | Stat1 (-/-) | A genomic library from strain 129 mice (Stratagene) was screened with a partial cDNA clone for mouse Stat1 (provided by C. Schindler). A 16.5 kb genomic clone (412C) en.... |
| 4. | Stat1 (-/-) | Genomic clones containing portions of the murine Stat1 gene were isolated from a lambdaFix II murine 129/Sv genomic library (Stratagene) by screening the library using t.... |
