TGF-beta 1
Multifocal inflammatory disease followed by a wasting syndrome
Multifocal infiltration of lymphocytes and macrophages into diverse organs. Increased adhesion of mononuclear leukocytes (MLN) to extracellular matrix and to endothelial cells in vitro. Blockage of MLN infiltration by synthetic fibronectin peptides
Decreased thymus size
Enlargement of lymph nodes
Elevated constitutive levels of IL-2 mRNA in the thymus
Elevated IL-2r mRNA in lymph nodes-
Cachexia
Death roughly 20 days after birth
Christ et al., 1994
Hines et al., 1994
TGF Beta 1 exhibits maternal rescue TGF Beta 1 null embryos and null newborn pups born to TGF-Beta 1 heterozygotes stained positive for TGF Beta 1 Severe cardiac abnormalities in null newborn mice born to null females
-
Letterio, 1994
-
Maternal rescue of transforming growth factor-beta 1 null mice.
Science 264, 1936-8 (1994) [94278499]
(View Citation format,Abstract format,MEDLARS format,ASN.1 format,Save As..., or 30 Related MEDLINE citations )
| Line Name | DNA Construct | |
|---|---|---|
| 1. | TGF-beta 1/neo | D3 ES cells (line 14-4) were electroporated with a 4.0 kb |
| 2. | TGF-beta1 (+/-) | A 5.7-kb fragment containing the first two exons of TGF-beta1 from clone pB2 was subcloned into the modified Bluescript vector (Stratagene) in which the Asp 718 site was.... |
| 3. | TGF-beta1 (+/-) (la | A 5.7-kb fragment containing the first two exons of TGF-beta1 from clone pB2 was subcloned into the modified Bluescript vector (Stratagene) in which the Asp 718 site was.... |
| 4. | TGF-beta1 (-/-) (la | A 5.7-kb fragment containing the first two exons of TGF-beta1 from clone pB2 was subcloned into the modified Bluescript vector (Stratagene) in which the Asp 718 site was.... |
| 5. | TGF-beta1 (-/-) | A 5.7-kb fragment containing the first two exons of TGF-beta1 from clone pB2 was subcloned into the modified Bluescript vector (Stratagene) in which the Asp 718 site was.... |
