u-PA
Normal fertility
Occasional fibrin deposition
Mice mutant for both t-PA and u-PA are subfertile
Ovulation reduced by 26% in t-PA and u-PA combined knockouts t-PA and u-PA are redundant systems which play a part in ovulation response t-PA and u-PA help other proteases in follicular wall degradation
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Leonardsson, 1995
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Ovulation efficiency is reduced in mice that lack plasminogen activator gene function: functional redundancy among physiological plasminogen activators.
Proc. Natl. Acad. Sci. U.S.A. 92, 12446-12450 (1995) [96109283]
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| Line Name | DNA Construct | |
|---|---|---|
| 1. | Alb-uPA founder 194 | A 14.5 kb SaII fragment of cosMuPA-1 containing the entire murine uPA gene (~6.7 kb) as well as 7.5 kb of 5'-flanking sequence and 0.3 kb of 3'-flanking sequence was sub.... |
| 2. | Alb-uPA founder 195 | A 14.5 kb SaII fragment of cosMuPA-1 containing the entire murine uPA gene (~6.7 kb) as well as 7.5 kb of 5'-flanking sequence and 0.3 kb of 3'-flanking sequence was sub.... |
| 3. | Alb-uPA founder 194 | A 14.5 kb SaII fragment of cosMuPA-1 containing the entire murine uPA gene (~6.7 kb) as well as 7.5 kb of 5'-flanking sequence and 0.3 kb of 3'-flanking sequence was sub.... |
| 4. | Alb-uPA founder 194 | A 14.5 kb SaII fragment of cosMuPA-1 containing the entire murine uPA gene (~6.7 kb) as well as 7.5 kb of 5'-flanking sequence and 0.3 kb of 3'-flanking sequence was sub.... |
| 5. | Alb-uPA founder 194 | A 14.5 kb SaII fragment of cosMuPA-1 containing the entire murine uPA gene (~6.7 kb) as well as 7.5 kb of 5'-flanking sequence and 0.3 kb of 3'-flanking sequence was sub.... |
| 6. | Alb-uPA founder 135 | A 14.5 kb SaII fragment of cosMuPA-1 containing the entire murine uPA gene (~6.7 kb) as well as 7.5 kb of 5'-flanking sequence and 0.3 kb of 3'-flanking sequence was sub.... |
| 7. | Alb-uPA founder 135 | A 14.5 kb SaII fragment of cosMuPA-1 containing the entire murine uPA gene (~6.7 kb) as well as 7.5 kb of 5'-flanking sequence and 0.3 kb of 3'-flanking sequence was sub.... |
| 8. | Alb-uPA founder lin | A 14.5 kb SaII fragment of cosMuPA-1 containing the entire murine uPA gene (~6.7 kb) as well as 7.5 kb of 5'-flanking sequence and 0.3 kb of 3'-flanking sequence was sub.... |
| 9. | Alb-uPA founder 135 | A 14.5 kb SaII fragment of cosMuPA-1 containing the entire murine uPA gene (~6.7 kb) as well as 7.5 kb of 5'-flanking sequence and 0.3 kb of 3'-flanking sequence was sub.... |
| 10. | Alb-uPA line 1944-6 | A 14.5 kb SaII fragment of cosMuPA-1 containing the entire murine uPA gene (~6.7 kb) as well as 7.5 kb of 5'-flanking sequence and 0.3 kb of 3'-flanking sequence was sub.... |
| 11. | Alb-uPA line 1353-8 | A 14.5 kb SaII fragment of cosMuPA-1 containing the entire murine uPA gene (~6.7 kb) as well as 7.5 kb of 5'-flanking sequence and 0.3 kb of 3'-flanking sequence was sub.... |
