XPA

Failure to show either obvious physical abnormalities or pathological alterations in mice
High susceptibility to ultraviolet beta or 9,10-dimethyl-1,2-benzanthracene-induced skin carcinogenesis
Defective in nucleotide-excision repair

Nakane, 1995

High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene.
Nature 377, 165-168 (1995) [95405470]
(View Citation format,Abstract format,MEDLARS format,ASN.1 format,Save As..., or 30 Related MEDLINE citations )

de Vries, 1995

Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA.
Nature 377, 169-173 (1995) [95405471]
(View Citation format,Abstract format,MEDLARS format,ASN.1 format,Save As..., or 30 Related MEDLINE citations )

( (xpa))

	Line Name	DNA Construct
1.	XPA (+/-)	The targeting construct MMXPA#5 comprises ~10 kb of the mouse xeroderma pigmentosum (XPA) gene (Ola129-derived DNA). After digestion of a genomic 5.5-kb BamHI
2.	XPA (+/-)	For construction of a targeting vector, a 5.7-kb BamHI XPA genomic fragment containing exons 3 and 4 was subcloned into a pUC19 plasmid. The 1.1-kb XhoI....
3.	XPA (-/-)	The targeting construct MMXPA#5 comprises ~10 kb of the mouse xeroderma pigmentosum (XPA) gene (Ola129-derived DNA). After digestion of a genomic 5.5-kb BamHI
4.	XPA (-/-)	For construction of a targeting vector, a 5.7-kb BamHI XPA genomic fragment containing exons 3 and 4 was subcloned into a pUC19 plasmid. The 1.1-kb XhoI....
5.	ERCC-1 (+/-)	PCR was used to isolate the exon 4-6 region of the excision repair cross complementing gene (ERCC-1) from ES cell DNA as a 2.3 kb fragment that was cloned into pBluescri....