XPC
Viability in homozygous mice
Lack of increased susceptibility to spontaneous tumor generation at one year of age
High susceptibility to ultraviolet-induced carcinogenesis compared to heterozygous mice
Display a spectrum of ultraviolet-exposure-related pathological skin and eye changes consistent with the human disease xeroderma pigmentosum group C
-
Sands, 1995
-
High susceptibility to ultraviolet-induced carcinogenesis in mice lacking XPC.
Nature 377, 162-165 (1995) [95405469]
(View Citation format,Abstract format,MEDLARS format,ASN.1 format,Save As..., 30 Related MEDLINE citations, 1 protein link, or 1 nucleotide link )
| Line Name | DNA Construct | |
|---|---|---|
| 1. | XPC (m1) (+/-) | A replacement targeting vector containing 1.8 kb of 5' homology and 3 kb of 3' homology was constructed with a marker for positive selection (hprt mini-gene) and negativ.... |
| 2. | XPC (m1) (-/-) | A replacement targeting vector containing 1.8 kb of 5' homology and 3 kb of 3' homology was constructed with a marker for positive selection (hprt mini-gene) and negativ.... |
