Table of Conents

SALIVARY GLAND TUMORS; CLINICAL AND PATHOLOGICAL FEATURES


PLEOMORPHIC ADENOMA (MIXED TUMOR)


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  • IMMUNOHISTOCHEMICAL FEATURES

  • Principal tumor cell is a modified myoepithelial cell

  • Cytokeratin (present)
  • Smooth muscle actin (present)
  • GFAP (variable)
  • Vimentin (present)
  • S-100 (present)

  • CHROMOSOMAL ABNORMALITIES

  • Normal karyotype
  • Chromosomal rearrangements
  • Chromosome 8 (band q12)
  • Chromosome 12 (q13-15)
    •