Table of Conents

ENDOMETRIAL METAPLASIAS, HYPERPLASIAS, ADENOCARCINOMAS


DIFFERENTIAL DIAGNOSIS OF ENDOMETRIAL HYPERPLASIA FROM ADENOCARCINOMA


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CONDITION

GLANDS
 

PROFILES

NUCLEI
 

Lining epithelium

Feature

Size

Feature

Size

Nucleoli

Mitosis

ADENOMATOUS HYPERPLASIA
  • Tall columnar
  • Single layered
  • Dilatated Irregular
  • No infolding
  • No outfolding
  • Variable
  • Smooth

    •  

  • Oval
  • Uniform
  • Small
  • Rround
  • Numerous (stroma, gland)

    • ATYPICAL HYPERPLASIA
  • Loss of polarity
  • Stratified epithelium
  • Irregular
  • Infolding
  • Outfolding
  • Variable
  • Irregular
  • Large
  • Variable
  • Large
  • Irregular
  • Numerous

    • ADENOCARCINOMA

    Loss of polarity
  • Irregular
  • Cribriform pattern
  • Bridging
  • Variable
    		•
  • Irregular
    		•
  • Large
  • Variable
    		•
  • Large
  • Irregular
  • Spiculated
    		•
  • Variable