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Item Image CEREBELLUM AS A SITE FOR PERCEPTION AND COGNITION

For long, cerebellum has been known for its involvement in motor coordination. This prevailing idea is perpetuated by the fact that lesions of the cerebellum lead to incoordinated movement and yet do not cause any easily detectable sensory deficit. Cerebellar cortex plays a crucial role in learning the timing of the movement and guides the learning in the deep nuclei. In addition, this hypothesis has been supported by electric stimulation and recording studies during a variety of movements. However, recent evidence shows that cerebellum exerts functions that go beyond this primary function. The hyptothesis is being developed that cerebellum is involved in perception and cognition. Gao et al, present data in the, April 1996 issue of Science, that give further credence to this hypothesis. Magnetic resonance imaging of the lateral cerebellar nucleus during passive and active sensory performances show that lateral cerebellum is actively involved with motor function as well as the perceptual and cognitive aspects of the tasks.

REFERENCES:

Gao H-H, Parsons LM, Bower JM, Xiong J, Li J, Fox PT: Cerebellum implicated in sensory acquisition and discrimination rather than motor control. Science, 272, 545-547, 1996

Fiez, 1996
Cerebellar contributions to cognition.
Neuron 16, 13-15 (1996) [96158917]
(no abstract available) (View Citation format,Abstract format,MEDLARS format,ASN.1 format,Save As..., or 30 MEDLINE neighbors )
Bresolin, 1994
Cognitive impairment in Duchenne muscular dystrophy.
Neuromuscul Disord 4, 359-369 (1994) [95072459]
(View Citation format,Abstract format,MEDLARS format,ASN.1 format,Save As..., or 30 MEDLINE neighbors )

Middleton, 1994
Anatomical evidence for cerebellar and basal ganglia involvement in higher cognitive function.
Science 266, 458-61 (1994) [95025944]
(View Citation format,Abstract format,MEDLARS format,ASN.1 format,Save As..., or 30 MEDLINE neighbors )

Decety, 1994
Mapping motor representations with positron emission tomography.
Nature 371, 600-2 (1994) [95021710]
(View Citation format,Abstract format,MEDLARS format,ASN.1 format,Save As..., or 30 MEDLINE neighbors )

Kim, 1994
Activation of a cerebellar output nucleus during cognitive processing.
Science 265, 949-51 (1994) [94329806]
(View Citation format,Abstract format,MEDLARS format,ASN.1 format,Save As..., or 30 MEDLINE neighbors )

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