HOT PAPERS; 1998

	FRONTIERS IN BIOSCIENCE; HOT PAPERS; 1998
	December 7, 1998 Andrew Koff, associate member of the molecular biology program at Sloan-Kettering Cancer Center, discusses possible actions of cyclin-dependent kinase inhibitors; David A. Cheresh, professor of immunology and vascular biology at the Scripps Research Institute in La Jolla, Calif., discusses anti-angiogenesis cancer-fighting therapies November 23, 1998 Ian A. Wilson, professor of molecular biology at The Scripps Research Institute in La Jolla, Calif; David N. Garboczi, intramural investigator at the National Institute of Allergy and Infectious Diseases in Bethesda, Md.; and Partho Ghosh, assistant professor of chemistry and biochemistry at the University of California, San Diego, discuss T-cells' recognition of antigens on cell surfaces November 9, 1998 Emad S. Alnemri, associate professor at The Kimmel Cancer Center at Thomas Jefferson University in Philadelphia, discusses the role of caspase prodomains in apoptosis Kazuo Masuko, director and chief of physicians at Masuko Memorial Hospital in Aichi-Ken, Japan, discusses the significance of the HGBV-C hepatitis virus October 12, 1998 Kei-ichi Nakayama, professor of molecular and cellular biology at Kyushu University, discusses p27's role on cell-cycle arrest in mice Miles Trupp, postdoctoral associate at University of California at San Francisco, discusses c-ret proto-oncogene as a cellular receptor October 12, 1998 David Baltimore, president of California Institute of Technology, discusses the role of NF-kappaB in apoptosis Christopher Michael O'Connor, associate director of the Duke Clinical Research Institute, Durham, N.C., discusses amlodipine's effect on heart failure September 28, 1998 Chris Glass, an associate professor of medicine at the University of California at San Diego, discusses the interaction of nuclear receptors and activation protein 1; Steven G. Younkin, director of research and professor of pharmacology at the Mayo Clinic in Jacksonville, Fla., discusses amyloid ß fragments and Alzheimer's disease September 14, 1998 Gerard D. Schellenberg, associate director for research, Geriatric Research Education and Clinical Center, Veterans Affairs Medical Center in Seattle, discusses aging, genetics, and Werner's syndrome David S. Bredt, an assistant professor of physiology at the University of California at San Francisco School of Medicine, discusses nitric oxide's role in stroke and Duchenne muscular dystrophy August 31, 1998 Inder M. Verma, American Cancer Society professor of molecular biology at the Salk Institute for Biological Studies, discusses the fine line between HIV as a virus and as a vector David D. Ho, director of the Aaron Diamond AIDS Research Center at Rockefeller University, New York, discusses the effect of genetics on whether HIV progresses to AIDS August 17, 1998 Ned Landau, of Aaron Diamond AIDS Research Center, discusses how HIV-1 uses the CCR5 coreceptor to infect the body John P. Moore and Alexandra Trkola, also of the Aaron Diamond AIDS Research Center, discuss HIV's interactions with the envelope protein gp120 and the coreceptor CD4 prior to gp120's link with CCR5 July 20, 1998 Gary M. Fox, of Amgen Inc.'s department of molecular genomics, discusses glial cell-derived neurotrophic factor and neurodegenerative diseases Paul A. Volberding, of the International AIDS Society-USA, discusses the value of HIV treatment guidelines July 6, 1998 Michael Rosenbaum, associate professor of pediatrics and medicine at Columbia University, discusses the role of leptin in obesity; Michael W. Schwartz, professor of medicine at the University of Washington, discusses the therapeutic value of leptin June 22, 1998 Ming-Xin Tang, professor of biostatistics at Columbia University, discusses the role of estrogen in Alzheimer's disease Roger K. Wolff, vice president of genetics at Progenitor Inc., explains how sometimes scientists have to extend their research to an "extended" family June 8, 1998 Frank M. Sacks, professor of medicine and nutrition at Brigham and Women's Hospital and Harvard University, discusses the significance of the CARE trial J. Craig Venter, president and director of The Institute for Genomic Research, explains how genetics keeps changing. May 25, 1998 Roger J. Davis, Howard Hughes Medical Institute investigator, discusses the significance of JNK Vishva M. Dixit, director of molecular oncology at Genentech Inc., explains how nano-electrospray tandem mass spectrometry helps in understanding cell signaling complexes May 11, 1998 Investigator Jonathan M. Graff discusses TGF ß signaling cascade Former researcher Gilbert S. Omenn explains the significance of the ß-Carotene and Retinol Efficacy Trial April 27, 1998 Investigator Vasily V. Ogryzko discusses the acetylation of chromatin and its role in genetic processes Microbiology and immunology professor Ronald A. DePinho discusses the role of the INK4a gene and its protein products in tumor suppression. April 13, 1998 Investigators Craig L. Hanis and Graeme I. Bell discuss the successes, and now the potential, of genetic research in Type 2 diabetes cell biology and neuroscience professors Jerry W. Shay and Woodring E. Wright review the relationship between telomerase and cell replication March 30, 1998 Virologist Edward A. Berger discusses the impact of fusin on understanding the path of HIV Cancer researcher Matthew Fero explains how the p27 protein helps to regulate cell growth March 16, 1998 Cardiology researcher Edward M. Gilbert discusses the effect of carvedilol, a nonspecific beta blocker, on morbidity and mortality of heart failure patients Medical geneticist Jeffrey L. Wrana reports on signal transduction events that occur in response to the transforming growth factor ß superfamily of growth and differentiation factors March 2, 1998 Cancer researcher Carlo Croce discusses his study that determined a link between deletion of the FHIT gene and the onset of lung cancer immunologist Michael J. Grusby reports on Stat6, a protein activated in response to interleukin-4 February 16, 1998 Virologists Thomas P. Leary and Isa K. Mushahwar discuss GB virus C, a novel member of the flavivirus family transmitted via blood. Molecular oncologist Vishva M. Dixit reports on ICE-LAP3, which plays a key role in initiating mammalian apoptosis. February 2, 1998 Biochemist David Wallach discusses his work providing evidence of the critical role of caspases in apoptosis Neurologist Wilma Wasco reports on her paper demonstrating the subcellular locales of the presenilins January 19, 1998 Neurologist R.G. Will discusses his much-publicized report of a new variant of Creutzfeldt-Jakob disease in the United Kingdom Medical researcher D. Scott Weigle reflects on his landmark study demonstrating that leptin induces satiety. January 5, 1998 Biotech company CEO David V. Goeddel explains the complexity of the tumor necrosis factor (TNF) receptor 1 signaling pathway pharmacologist Michael Karin discusses dissection of the signals initiated by TNF receptor 1 Source: The scientist