[Frontiers in Bioscience 1, d72-90, July 1, 1996]
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INTERACTIONS BETWEEN THE COMPONENTS OF THE HUMAN NADPH OXIDASE: A REVIEW ABOUT THE INTRIGUES IN THE PHOX FAMILY

Jeanette H. W. Leusen1,2, Arthur J. Verhoeven1 and Dirk Roos1,3

1 Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands.

2Department of Pediatrics, Emma's Children Hospital, Academic Medical Center, Amsterdam, The Netherlands.

Received 04/15/96; Accepted 05/05/96; On-line 07/01/96

TABLE OF CONTENTS

1. Abstract
2. NADPH oxidase
2.1. Mechanisms of activation of the oxidase
3. Chronic Granulomatous Disease (CGD)
4. The components of the NADPH oxidase.
4.1. Cytochrome b558
4.2. Rap1A
4.3. p47-phox
4.4 p67-phox
4.5. p40-phox
4.6. p21-rac
5. Activation of the NADPH oxidase
5.1. Cell-free system
5.2.Important domains within cytochrome b558
5.3. Interactions between the cytosolic components
5.4. Role of phosphorylations in activation of the oxidase
5.5. Role of rac and Rap1A in activating the oxidase
5.6. NADPH oxidase: cell-free system vs intact cells
6. Acknowledgments
7. References
8. Entire manuscript