[Frontiers in Bioscience 1, e78-86, August 1,1996]
Reprints
PubMed
CAVEAT LECTOR



OXIDATIVE STRESS AND ROLE OF ANTIOXIDANTS IN NORMAL AND ABNORMAL SPERM FUNCTION

Suresh C. Sikka, Ph.D., HCLD

Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana, USA

Received 05/30/96; Accepted 07/02/96; On-line 08/01/96

11. REFERENCES

1. M. Hull, C. Glazener, N. Kelly, D. Conway, P. Foster, R. Hunton, C. Coulson, P. Lambert, E. Watt, & K. Desai: Population study of causes, treatment and outcome of infertility. Br Med J 291, 1693-7 (1985)

2. WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction. Cambridge Univ Press, Cambridge, 3rd Edition (1992)

3. M. Sigman, L. Lipshultz, & S. Howards: Evaluation of the subfertile male. In: Infertility in the male. Eds: Lipshultz LA, Howards SS: Chuchill Livingstone, NY (1991)

4. N. Bar-Chama, D. Lamb. Evaluation of sperm function. What is available in the modern andrology laboratory? Urologic Clinics of North Am. 21, 433-46 (1994)

5. S.C. Sikka, M. Rajasekaran, & W. J. Hellstrom: Role of oxidative stress and antioxidants in male infertility. J Androl 16, 464-8 (1995)

6. D. A. Joyce: Oxygen radicals in disease. Adverse Drug Reaction Bull 127, 476-9 (1987)

7. W. Koppenol, J. Moreno, W. Pryor, H. Ischiropoulos & J.S. Beckman: Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide. Chemical Res in Toxicol 5, 834-42 (1992)

8. C. Gagnon, A. Iwasaki, E. de Lamirande, N. Kovalski: Reactive oxygen species and human spermatozoa. Ann N Y Acad Sci 637, 436-44 (1991)

9. R. J. Aitken, J.S. Clarkson: Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa. J Reprod Fertil 81, 459-69 (1987)

10. R.J. Aitken, D. Buckingham, K. West, F.C. Wu, K. Zikopoulos, & D.W. Richardson: Differential contribution of leukocytes and spermatozoa to the generation of reactive oxygen species in the ejaculates of oligozoospermic patients and fertile donors. J Reprod Fertil 94, 451-62 (1992)

11. H. Wolff, & D.J. Anderson: Immunohistologic characterization and quantitation of leucocyte subpopulations in human semen. Fertil Steril 49, 497-504 (1988)

12. E. Kessopoulou, M. J. Tomlinson, C.L. Barratt, A. E. Bolton, & I. D. Cooke: Origin of reactive oxygen species in human semen: spermatozoa or leucocytes? J Reprod Fertil 94, 463-70 (1992)

13. C. Krausz, C. Mills, S. Rogers, S.L.Tan, R.J.Aitken: Stimulation of oxidant generation by human sperm suspensions using phorbol esters and formyl peptides:relationships with motility and fertilization in vitro. Fertil Steril 62, 599-605 (1994)

14. A. Iwasaki, & C. Gagnon: Formation of reactive oxygen species in spermatozoa of infertile patients. Fertil Steril 57, 409-416 (1992)

15. R. J. Aitken, K. M. West, D.W. Buckingham: Leoukocyte infiltration into the human ejaculate and its association with semen quality, oxidative stress, and sperm function. J Androl 15, 343- 352 (1994)

16. M. Rajasekaran, W.J. Hellstrom, R.K. Naz, & S.C. Sikka: Oxidative stress and interleukins in seminal plasma during leukocytospermia. Fertil Steril 64, 166-171 (1995)

17. M. Rajasekaran, W.J. Hellstrom, & S.C. Sikka: Quantitative assessment of cytokines (GRO-alpha and IL-10) in human seminal plasma during genitourinary inflammation. Am J Reprod Immun.36, in press (1996)

18. J.G. Alvarez, J.C. Touchstone, L. Blasco, & B.T. Storey: Spontaneous lipid peroxidation and production of hydrogen peroxide and superoxide in human spermatozoa. Superoxide dismutase as major enzyme protectant against oxygen toxicity. J Androl 8, 338-348 (1987)

19. D.S. Irvine: Glutathione as a treatment for male infertility. Reviews of Reprod 1, 6-12 (1996)

20. V. Darley-Usmar, H. Wiseman, & Halliwell: Nitric oxide and oxygen radicals: a question of balance. FEBS Letters 369, 131-135 (1995)

21. M. Rosselli, R.K. Dubey, B. Imthurn, E. Macas, & P.J. Keller: Effects of nitric oxide on human spermatozoa: evidence that nitric oxide decreases sperm motility and induces sperm toxicity. Human Reprod 10, 1786-1790 (1995)

22. W.J.G. Hellstrom, M. Bell, R. Wang, & S.C. Sikka: Effect of sodium nitroprusside on sperm motility, viability, and lipid peroxidation. Fertil Steril 61, 1117-1122 (1994)

23. J.B. Hibbs Jr, Z. Vavrin & RR. Taintor: L-arginine is required for the expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells. J Immunol 138, 550-65 (1987)

24. J.S. Beckman,T.W. Beckman, & J. Chen: Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87,1620-1624 (1990)

25. E. de Lamirande, & C. Gagnon: Reactive oxygen species and human spermatozoa. I. Effects on the motility of intact spermatozoa and on sperm axonemes; and II. Depletion of adenosine triphosphate plays an important role in the inhibition of sperm motility. J Androl 13, 368-386 (1992)

26. L. Ernster: Lipid peroxidation in biological membranes: mechanisms and implications. In: Active oxygen, lipid peroxides and antioxidants. Ed: Yagi K, CRC Press, Boca Raton, 1-38 (1993)

27. D.B. Taourel, M.C. Guerin, & J. Torreilles. Is melonaldehyde a valuable indicator of lipid peroxidation? Biochem Pharmacol 44, 985-88 (1992).

28. A. Lenzi, M. Picardo, L. Gandini, F. Lombardo, O. Terminali, S. Passi, & F. Dondero: Glutathione treatment of dyspermia: effect on the lipoperoxidation process. Hum Reprod 9, 2044-2050 (1994)

29. J.M. Cummins, A.M. Jequier, & K. Raymond: Molecular biology of human male infertility: links with aging, mitochondrial genetics, and oxidative stress? Mol Rep and Dev 37, 345-362 (1994)

30. R.J. Aitken, M. Paterson, H. Fisher, D.W. Buckingham, & M. van Duin: Redox regulation of tyrosine phosphorylation in human spermatozoa and its role in the control of human sperm function. J Cell Sci 108, 2017-2025 (1995)

31. H.I. Calvin, G.W. Cooper & E.W. Wallace: Evidence that selenium in rat sperm is associated with a cysteinre-rich structural proteins of the mitochondrial capsule. Gamete Res.4, 139- 145 (1981)

32. S.C. Sikka, W.J.G. Hellstrom, & R.K. Naz: Pentoxifylline: Role in management of male infertility/mechanisms of action. Mol Androl 5, 220-231 (1993).

33. J. Derrick Jr, & B. Dahlberg: Male genital infections and sperm viability. In:Human semen and fertility regulation in men. Ed:Hafez ESE, CV Mosby Co., NY 389-397 (1976)

34. W.J.G. Hellstrom, & D.E. Neal Jr.: Diagnosis and therapy of male genital tract infections. In: Infertlity and Reproductive Medicine Clinics of North America. Eds: Diamond MP, DeCherney, Overstreet JW. WB Saunders Co., PA 399-411 (1992)

35. V. Nikkanen, M. Gronroos, & J. Suominen: Silent infections in male accessory genital organs and male infertility. Andrologia 11, 236-241 (1979)

36. L. Johnsosn: Evaluation of the human testis and its age-related dysfunction. Prog Clin Biol Res 302, 35-67 (1989)

37. B. Rao, J.C. Soufir, M. Martin, & G. David: Lipid peroxidation in human spermatozoa as related to midpiece abnormalities and motility. Gamete Res 24,127-134 (1989)

38. G. Huszar, & L. Vigue: Correlation between the rate of lipid peroxidation and cellular maturity as measured by creatine kinase activity in human spermatozoa. J Androl 15, 71-77 (1994)

39. J.B. Kerr: Functional cytology of the human testis. Baillieres Clin Endocrin Metab 6, 235- 250 (1992)

40. W. Reichel: Lipofuscin pigment accumulation and distribution in various organisms as a function of age. J Gerontol 23,145-153 (1968)

41. M. Rajasekaran, W.J. Hellstrom, R.L. Sparks, & S.C. Sikka: Sperm damaging effects of electric current: possible role of free radicals. Reprod Toxicol 8, 27-432 (1994)

[Table of Contents ] [Previous Section]