|[Frontiers in Bioscience 2, d298-308, June 15, 1997]|
TRANSGENIC RABBIT MODELS FOR THE STUDY OF ATHEROSCLEROSIS
John M. Taylor and Jianglin Fan
Gladstone Institute of Cardiovascular Disease, the Department of Physiology, and the Cardiovascular Research Institute, University of California, San Francisco, CA
The rabbit is an important model for the study of the relationship between plasma cholesterol metabolism and atherosclerosis. To provide new experimental tools, transgenic rabbits have been generated in which individual genes involved in plasma lipoprotein metabolism have been overexpressed. In each case, alterations in plasma cholesterol and lipoprotein distribution were observed. Research on additional transgenic models is also underway that will extend these studies further, exploiting the unique advantages and characteristics of the rabbit. We can expect that these transgenic animals will bring new insights into the mechanisms that contribute to the development of atherosclerosis, expanding the power of the rabbit model for the study of cardiovascular disease.